WMEB became an official radio station in January 1964 when the Federal Communications Commission (FCC) licensed the station to operate on the frequency of 91.9 MHz FM, and its callsign became WMEB-FM.

Originally broadcasting between 4-10pm, WMEB was a "mix of music, news, and informational programming." The station remained with this format throughout most of the 1960s.

In the 1970s, the station became more progressive rock-based in its format as more and more artists were releasing on vinyl records.

There was still a place for news and public service announcements, but by the 1980s, WMEB had joined many other college radio stations in helping little-known bands make it onto the charts.